Journal: Scientific Reports

Article Title: Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods

doi: 10.1038/s41598-021-92923-4

Figure Lengend Snippet: CMR scanning protocol for assessing T1 time dependencies. After planning, native T1-mapping is performed at rest using ShMOLLI, MOLLI Low HR, and MOLLI High HR. Stress T1-mapping is performed following administration of regadenoson (IV 400 mcg). This consists of four ShMOLLI measurements to cover the initial transition period and peak stress, followed by blocks of interleaved ShMOLLI and MOLLI variants. First-pass perfusion imaging is performed after gadolinium injection (0.05 mmol/kg). Allowing 4 min for the reconstruction of MBF data, stress is reversed with aminophylline (IV 100 mg) followed immediately by the same pattern of ShMOLLI and MOLLI acquisitions. Rest perfusion is performed after a second dose of gadolinium (0.05 mmol/kg), followed immediately by T1-mapping.

Article Snippet: Dr Piechnik has patent authorship rights for U.S. patent 9285446 B2 (systems and methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] cardiac gated mapping of T1), granted March 15, 2016; all rights transferred to Siemens Medical.

Techniques: Imaging, Injection

Journal: Scientific Reports

Article Title: Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods

doi: 10.1038/s41598-021-92923-4

Figure Lengend Snippet: Modified second CMR scanning protocol for assessing stress T1 and MBF. Native T1-mapping is performed at rest using ShMOLLI, MOLLI Low HR, and MOLLI High HR in basal, mid-ventricular, and apical slice positions. Stress T1-mapping is performed following administration of regadenoson (IV 400 mcg) in the basal, apical, and mid-ventricular slices as illustrated. Stress is reversed with aminophylline (IV 100 mg) at ~ 25 min. Rest perfusion and late gadolinium enhancement images are acquired.

Article Snippet: Dr Piechnik has patent authorship rights for U.S. patent 9285446 B2 (systems and methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] cardiac gated mapping of T1), granted March 15, 2016; all rights transferred to Siemens Medical.

Techniques: Modification

Journal: Scientific Reports

Article Title: Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods

doi: 10.1038/s41598-021-92923-4

Figure Lengend Snippet: Regadenoson stress effects on heart rate ( A ), MBF ( B ) and dT1 ( C ) with overlaid mono-exponential decay models \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$y=a*exp(-x/b)$$\end{document} y = a ∗ e x p ( - x / b ) . In panel ( B ), time point 0 corresponds to the baseline conditions and is included to illustrate MBF at rest. In panel ( C ) the decay time b has been established for ShMOLLI only, and only amplitudes scaled to best fit other MOLLI variants; the dashed lines mark the extrapolation of the MOLLI models beyond the respective data ranges. The rising part of the T1 response to stress (dotted green line), HR and MBF responses (fitted to relative changes and transposed) are to guide the eye only.

Article Snippet: Dr Piechnik has patent authorship rights for U.S. patent 9285446 B2 (systems and methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] cardiac gated mapping of T1), granted March 15, 2016; all rights transferred to Siemens Medical.

Techniques:

Journal: Scientific Reports

Article Title: Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods

doi: 10.1038/s41598-021-92923-4

Figure Lengend Snippet: Differences in T1 measurements between methods for rest, stress, and post-contrast T1.

Article Snippet: Dr Piechnik has patent authorship rights for U.S. patent 9285446 B2 (systems and methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] cardiac gated mapping of T1), granted March 15, 2016; all rights transferred to Siemens Medical.

Techniques:

Journal: Scientific Reports

Article Title: Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods

doi: 10.1038/s41598-021-92923-4

Figure Lengend Snippet: Relationship between T1-mapping variants. Linear fit for T1-mapping variants on native rest, stress, and post-contrast T1 (A) and analysis of differences plot comparing the results from MOLLI variants against all interpolated ShMOLLI values (B). The blue solid line (B) indicates the mean difference between ShMOLLI and MOLLI. The red dotted lines (B) indicate the 95% limit of agreement for all pooled MOLLI compared to ShMOLLI. Post-contrast T1 values are measured using the MOLLI 4(1)3(1)2 sequence with Low HR and High HR sub-variants; stress T1 values are measured using the MOLLI 5(3)3 sequence and Low HR and High HR sub-variants.

Article Snippet: Dr Piechnik has patent authorship rights for U.S. patent 9285446 B2 (systems and methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] cardiac gated mapping of T1), granted March 15, 2016; all rights transferred to Siemens Medical.

Techniques: Sequencing

Journal: Scientific Reports

Article Title: Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods

doi: 10.1038/s41598-021-92923-4

Figure Lengend Snippet: Measures of intra-individual variability across different T1-mapping variants measured by RMSE[CV].

Article Snippet: Dr Piechnik has patent authorship rights for U.S. patent 9285446 B2 (systems and methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] cardiac gated mapping of T1), granted March 15, 2016; all rights transferred to Siemens Medical.

Techniques: